Description
InformationElimusertib (BAY-1895344) is a very potent and highly selectiveATR (ataxia telangiectasia and Rad3-related)inhibitor with IC50 of 7 nM. Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78 nM.TargetsATR (Cell-free assay) 7 nMIn vitroBAY-1895344 inhibits tumor cell growth and viability and exhibits potent antiproliferative activity in a broad spectrum of human tumor cell lines.In vivoBAY 1895344 exhibits strong monotherapy efficacy in cancer xenograft models that carry DNA damage repair deficiencies.Cell Research(from reference)Cell lines：HT-29 cells, M059J cells, 38 cancer cell lines Concentrations：3–300 nM Incubation Time：72 to 96 hours